I also noticed that whenever you overwrite a saved game, and load up from there, the game will sometimes get buggy.
Some examples: Dana will be in casual clothes in the office instead of her suit. And the main task given to you by a character, at that point of time, will not appear in the job list. So have fun clicking everywhere each time you receive a new mini-task, since you don't know what he/she assigned to you, all the way till you are thanked for a job well done.
I must add, the clothes bug will resolve itself when you finish the day and head to bed.
The only crash I had was when I choose the option "Hang up" while playing the mystery storyline.
I know you might ask me, why don't I save in a new slot? But since I save for almost every day, it's not very practical.